Venom Elimination
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In the present work, we studied the effects of antivenom, constituted with either F (ab‘)2 or Fab, on the processes of absorption and elimination of Vipera aspis venom in experimentally
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The shift of venom mass to tissues is fundamentally due to two factors: first, it is due to the tissue sites “strongly” binding venom (the so-called high-affinity receptors) and
The mechanisms by which antivenom neutralizes the venom are still poorly understood. In the present work, we studied the effects of antivenom, constituted with either
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Author summary Hyaluronidases are known as the venom components responsible for disseminating toxins from the injection site to the victim’s organism. Therefore,
Detoxification Efficiency
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In this review, the present-day and summarized knowledge of the laboratory and clinical findings on the i.v. and i.m. routes of antivenom administration is provided, with a
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It seems that the venom neutralization in the lymphatics may be of importance for the clinical outcome, at least when the i.v. route is applied. The role of i.m. administered antivenom in the
In general, the disposition of snake venom was described by a two-compartment model consisting of a rapid distribution phase and a slow elimination phase, with half-lives of 5 to 48 min and 0.8
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In the present work, we studied the effects of antivenom, constituted with either F (ab′) 2 or Fab, on the processes of absorption and elimination of Vipera aspis venom in experimentally envenomed rabbits.
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Studies on venom toxicokinetic have revealed a rapid distribution phase of toxins followed by a slow elimination phase. 13 However, venoms having different toxin compositions
We conducted this study to assess the effectiveness of antivenom in the recovery of clotting parameters in patients consulting tardily after SB envenoming in French Guiana. The primary endpoint of our study was to investigate the time needed
In this review, the present-day and summarized knowledge of the laboratory and clinical findings on the i.v. and i.m. routes of antivenom administration is provided, with a special emphasis on
In this review, the present-day and summarized knowledge of the laboratory and clinical findings on the i.v. and i.m. routes of antivenom administration is provided, with a special emphasis on
Recombinant antibodies and smaller functional units are now emerging as credible alternatives and constitute a source of still unexploited biomolecules capable of neutralizing venoms.
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(A) Distribution profiles for different antibody formats, showing their volume of distribution (V d ). (B) Elimination mechanism for different antibody formats, indicating their elimination
Detoxification Efficiency (CT 08) is a neuron located on the Neuronal menu. One curative element is now enough to cure all forms of intoxication. Once a neuron is revealed, the neuron will need
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Improved purification of the antivenom by using immunoglobulin fragments has lead to increased tolerance and efficiency of antivenom. The respective advantages and
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In this review, the present-day and summarized knowledge of the laboratory and clinical findings on the i.v. and i.m. routes of antivenom administration is provided, with a
Download scientific diagram | Schematic representation of the structural pharmacokinetic model for P. porphyriacus venom and pharmacodynamic model for creatine kinase time course. F1 is
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