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The Interplay Of Supercoiling And Thymine Dimers In Dna

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Thymine dimers are a major mutagenic photoproduct induced by UV radiation. While they have been the subject of extensive theoretical and experimental investigations, questions of how

While they have been the subject of extensive theoretical and experimental investigations, questions of how DNA supercoiling affects local defect properties, or, conversely, how the

The oxDNA thymine dimer model (highlighted in cyan

Structural interplay between DNA-shape protein recognition and ...

stranded DNA as a function of external twist and force. Compared to undamaged DNA, the presence of a thymine dimer lowers the supercoiling densities at which plectonemes and

Thymine dimer-induced tip-bubbles also pin plectonemes, which may help repair enzymes to locate damage. We hypothesize that the interplay of supercoiling and local defects

  • The interplay of supercoiling and thymine dimers in DNAThe interplay of supercoiling and thymine dimers in DNA
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  • The oxDNA thymine dimer model .
  • The interplay of supercoiling and thymine dimers in DNA.

We hypothesize that the interplay of supercoiling and local defects plays an important role for a wider set of DNA damage repair systems.

The interplay of supercoiling and thymine dimers in DNA release_hdz7vrqbbrc57a2tfzeoyjbp4m Closing the ring: Links between SMC proteins and chromosome partitioning, condensation,

By using atomistic molecular dynamics simulations on DNA minicircles, we reveal, for the first time, the reciprocal influence between a DNA-bending protein and supercoiling. On one hand,

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Thymine dimers are a major mutagenic photoproduct induced by UV radiation. While they have been the subject of extensive theoretical and experimental investigations, questions of how

stranded DNA as a function of external twist and force. Compared to undamaged DNA, the presence of a thymine dimer lowers the supercoiling densities at which plectonemes and

Thymine dimers are a major mutagenic photoproduct induced by UV radiation. While they have been the subject of extensive theoretical and experimental investigations, questions of how

To demonstrate the feasibility of modelling thymine dimers with oxDNA, we therefore need to ensure that the model can reproduce well-established structural and

We hypothesize that the interplay of supercoiling and local defects plays an important role for a wider set of DNA damage repair systems.

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Thymine dimer-induced tip-bubbles also pin plectonemes, which may help repair enzymes to locate damage. We hypothesize that the interplay of supercoiling and local defects plays an

  • Videos von The interplay of supercoiling and thymine dimers in dna
  • The oxDNA thymine dimer model (highlighted in cyan
  • The interplay of supercoiling and thymine dimers in DNA

Chemistry at the interface with Biology and Medicine. Energy and Sustainable Chemistry. Innovative Measurement and Photon Science

stranded DNA as a function of external twist and force. Compared to undamaged DNA, the presence of a thymine dimer lowers the supercoiling densities at which plectonemes and

Thymine dimer-induced tip-bubbles also pin plectonemes, which may help repair enzymes to locate damage. We hypothesize that the interplay of supercoiling and local defects

Mutation II

While they have been the subject of extensive theoretical and experimental investigations, questions of how DNA supercoiling affects local defect properties, or, conversely, how the

logically relevant supercoiling densities and forces, thymine dimers can preferentially segregate to the tips of the plectonemes, where they enhance the probability of a localized tip-bubble.

Standard errors for the mean bending angles obtained using MD simulations are less than 1.3 • from publication: The interplay of supercoiling and thymine dimers in DNA | Thymine dimers

The interplay of supercoiling and thymine dimers in DNA . Article. Full-text available. Feb 2022; Wilber Lim; Ferdinando Randisi; Jonathan P. K. Doye; Ard A Louis; Thymine dimers are a

Chemistry at the interface with Biology and Medicine. Energy and Sustainable Chemistry. Innovative Measurement and Photon Science

Thymine dimers are a major mutagenic photoproduct induced by UV radiation. While they have been the subject of extensive theoretical and experimental investigations, questions of how

Thymine dimers are a major mutagenic photoproduct induced by UV radiation. While they have been the subject of extensive theoretical and experimental investigations,

Compared to undamaged DNA, the presence of a thymine dimer lowers the supercoiling densities at which plectonemes and bubbles occur. For biologically relevant supercoiling densities and

In this paper, we focus on the interaction between supercoiling and inhomogeneities caused by thymine dimers, the most common of several types of mutagenic lesions caused by UV irradiation

stranded DNA as a function of external twist and force. Compared to undamaged DNA, the presence of a thymine dimer lowers the supercoiling densities at which plectonemes and

Thymine dimers are a major mutagenic photoproduct induced by UV radiation. While they have been the subject of extensive theoretical and experimental investigations, questions of how

Thymine dimers are a major mutagenic photoproduct induced by UV radiation. While they have been the subject of extensive theoretical and experimental investigations,