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Testing The Super-Enhancer Concept

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Here, we discuss the concept of super-enhancers and review the features that define regions of the genome as such, outlining areas of consensus and points of uncertainty. We discuss

The term ’super-enhancer‘ has been used to describe groups of putative enhancers in close genomic proximity with unusually high levels of Mediator binding, as measured by chromatin

Testing the super-enhancer concept_2021_Gerd A. Blobel

(PDF) Super Enhancer Profiles Identify Key Cell Identity Genes During ...

Article “Testing the super-enhancer concept” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking science and technology

Does the concept of a super-enhancer help us to understand principles and mechanisms of gene regulation? At some loci, super-enhancers have constituent enhancers that can act in a highly

Addresses. The Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].

  • What are Super-Enhancers?
  • Testing the super-enhancer concept.
  • Testing the super-enhancer concept. — Oxford Stem Cell Institute
  • Modular super-enhancer controls retinal devel

许多增强子在基因组中以簇的形式存在，这导致了“超级增强子”一词的诞生。在这个观点中，五位专家讨论了我们对增强子簇的生物学理解，我们如何负责任地研究它们的功能，以及他们对增

Blobel, Gerd A, Higgs, Douglas R, Mitchell, Jennifer A, Notani, Dimple and Young, Richard A. 2021. „Testing the super-enhancer concept.“ Nature Reviews Genetics, 22 (12). Version:

MIT Open Access Articles Testing the super-enhancer concept

Here we review the identification and composition of super-enhancers, describe links between super-enhancers, gene regulation and disease, and discuss the functional significance of

Testing the super-enhancer concept Nat Rev Genet. 2021 Dec;22(12):749-755. doi: 10.1038/s41576-021-00398-w. Epub 2021 Sep 3. Authors Gerd A Blobel 1 , Douglas R Higgs 2

Testing the first modular super-enhancer. A super-enhancer of Vsx2 controls the complex and dynamic pattern of expression involved in retinal development. “While thousands

Abstract: Many enhancers exist as clusters in the genome, which has led to the coining of the term ‘super-enhancer’. In this Viewpoint, five experts discuss our biological understanding of

Testing the first modular super-enhancer. A super-enhancer of Vsx2 controls the complex and dynamic pattern of expression involved in retinal development. While thousands

Testing the super-enhancer concept. Nat Rev Genet. 2021 Sep 3. doi: 10.1038/s41576-021-00398-w. Epub ahead of print. PMID: 34480110. CTCF and transcription influence chromatin

To address this challenge, we developed enhancer scrambling, a high-throughput strategy to generate stochastic inversions and deletions of targeted enhancer regions by

The super-enhancer concept is partially based on the observation that cell identity maintenance in mESCs is highly sensitive to inhibition of the transcriptional coactivator

Phenotypic reversion of the gypsy-induced mutation scD1 of Drosophila melanogaster by replicative transposition of a sc enhancer to the yellow gene and by mutations

The super-enhancer concept is partially based on the observation that cell identity maintenance in mESCs is highly sensitive to inhibition of the transcriptional coactivator Mediator and cohesin

CRISPR interference and activation validated the function of a previously unrecognized unidirectional flow-induced super-enhancer that upregulates antioxidant genes

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Here we review the identification and composition of super-enhancers, describe links between super-enhancers, gene regulation and disease, and discuss the functional

Testing the super-enhancer concept. Testing the super-enhancer concept. Title: Testing the super-enhancer concept. Publication Type: Journal Article: Year of Publication: 2021: Authors:

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其它: 期刊：Nature Reviews Genetics 作者：Gerd A. Blobel; Douglas R. Higgs; Jennifer A. Mitchell; Dimple Notani; Richard A. Young 出版日期：2021-12-01

In this Viewpoint, five experts discuss our biological understanding of enhancer clusters, how we can responsibly study their functions, and their opinions on whether names

Human gene expression is controlled from distance via enhancers, which can form longer „super-enhancer“-regions of intense regulatory activity. Whether super-enhancers

In this review, we summarize the roles of super-enhancers in cancer biology, with a particular focus on hematopoietic malignancies, in which multiple super-enhancer alteration mechanisms

Testing the first modular super-enhancer. A super-enhancer of Vsx2 controls the complex and dynamic pattern of expression involved in retinal development. “While thousands

013456789;:Severalenhancerclustersinthegenomehavebeendescribedassuper-enhancers.Couldyoudescribeyourthoughtsonthecoiningoftheterm‘super

Hay, D. et al. Genetic dissection of the α-globin super-enhancer in vivo. Nat. Genet. 48, 895–903 (2016). Cited by 38 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5

Super-enhancers (SEs) are typically located in the regulatory regions of genes, driving high-level gene expression. Identifying SEs is crucial for a deeper understanding of