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Reviews

Pathology And Hippocampal Atrophy In Alzheimer’s Disease

Di: Everly

As a characteristic feature of Alzheimer´s disease (AD) hippocampal atrophy (HA) can be demonstrated in the majority of patients by using neuroimaging techniques in particular

Pathology and hippocampal atrophy in Alzheimer’s disease.

Hippocampal atrophy: Not only an indicator for Alzheimer’s disease - To ...

Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used in clinical routine and research field, largely contribut

The three-dimensionally reconstructed hippocampal formations in three patients with very severe, immobile Alzheimer disease (AD) and three age-matched nondemented

This review focuses specifically on hippocampal hyperexcitability, a pathology that is sometimes detectable years before diagnosis, which has been observed in individuals with aMCI. We

  • A meta-analysis of hippocampal atrophy rates in Alzheimer’s disease
  • Do Frontoparietal Regions Shrink First in Preclinical Alzheimer’s?
  • Potential predictors of hippocampal atrophy in Alzheimer’s disease
  • Pathology and hippocampal atrophy in Alzheimer’s disease.

Second, there are differences in hippocampal atrophy in the three clinical FTLD subtypes: FTD showed bilateral hippocampal atrophy comparable to Alzheimer’s disease; in SD bilateral

Longitudinal hippocampal atrophy was tied to cognitive decline independently of amyloid-beta or tau in clinically normal older adults, suggesting that non-Alzheimer’s

Aβ pathology potently accelerates the initiation and propagation of tau pathology. Strong clinical evidence emerges from studies of familial AD patients harboring pathogenic

Longitudinal MRI is a powerful tool that allows the assessment of progression of brain changes over multiple imaging time-points and has been increasingly employed in the

Atrophy is regarded a sensitive marker of neurodegenerative pathology. In addition to confirming the well-known presence of decreased global grey matter and hippocampal volumes in

Concomitant non-AD pathologies include cerebrovascular disease (forms of small vessel disease such as cerebral amyloid angiopathy and hypertensive arteriopathy) and other

Hippocampus is the significant component of the limbic lobe, which is further subdivided into the dentate gyrus and parts of Cornu Ammonis. It is the crucial region for

Keywords: Alzheimer’s disease, atrophy patterns, multiple pathologies, amyloid-beta, tau, cerebrovascular burden. Citation: Mohanty R, Ferreira D and Westman E (2024)

Recent studies highlight distinct patterns of cortical atrophy between amnestic (typical) and non-amnestic (atypical, with subtypes: behavioural, dysexecutive, logopenic and

Josephs et al. tackles the concept of the pathology responsible for the variable rates of hippocampal atrophy in Alzheimer’s disease. It has been noted that there are four main

Hippocampal sclerosis of aging is a key Alzheimer’s disease mimic: clinical-pathologic correlations and comparisons with both alzheimer’s disease and non-tauopathic

Hippocampal atrophy characterizes symptomatic Alzheimer’s disease, but a study in the April 28 JAMA Neurology makes the case that degeneration actually begins in the

In The Lancet Neurology, the study by Keith Josephs and colleagues 7 tackles the concept of the pathology responsible for the variable rates of hippocampal atrophy in Alzheimer’s disease.

Hippocampal atrophy is used as a marker in the diagnosis of Alzheimer’s disease. It can be demonstrated at very early stages of the disease. Little is known about hippocampal

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive loss of memory and deterioration of cognitive functions. 1 There is increasing

Taking Alzheimer’s disease (AD) neuropathology as an example, we know that the accumulation of abnormal structures such as senile plaques and neurofibrillary tangles is a

Memory impairment is a characteristic early sign of Alzheimer’s Disease (AD) and atrophy of the memory related medial temporal structures, particularly the hippocampal formation, is one of its earliest macroscopical hallmarks and has

Hippocampal sclerosis of aging is a key Alzheimer’s disease mimic: clinical-pathologic correlations and comparisons with both alzheimer’s disease and non-tauopathic frontotemporal

In this review, we discuss the recent advances and findings on the topic of glial heterogeneity, particularly focusing on the relationships of these cells with AD hallmarks (e.g., amyloid beta

Sleep disturbances are associated with the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and primary tauopathies. Here we demonstrate that

Hippocampal atrophy is a proposed biomarker for Alzheimer’s disease (AD). Yet the hippocampus—a key structure involved in learning and memory—is vulnerable to

Background: The hippocampus and hippocampal subfields have been found to be diversely affected in Alzheimer’s Disease (AD) and early stages of Alzheimer’s disease by

Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer’s disease (AD). However, cohorts and methods used to determine such rates are

Neuropathological and neuroimaging studies have identified several (endo-)phenotypes of Alzheimer’s disease (AD), suggesting a substantial heterogeneity in cerebral