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Reviews

Optic Nerve Regeneration: Potential Treatment Approaches.

Di: Everly

Signal Transduction and Targeted Therapy – Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan

Damage to the optic nerve can lead to irreversible blindness. A newly investigated regeneration factor could change that, UConn researchers report in the May 2024

Modeling Optic Nerve Regeneration | Department of Ophthalmology and ...

Optic Nerve Regeneration: How Will We Get There?

Investigation into optic nerve regeneration offers critical information for developing novel therapies for optic nerve disorders, such as glaucoma, optic neuritis, and traumatic optic

models of optic neuropathy.31e33 Metabolic regulation plays a major role in the maintenance and, possibly, regeneration of photoreceptor outer segments.34 Tremendous advances in optic

20,65,66 Other groups hope to exploit the regenerative capacity of the PNS by using sciatic nerve grafts to facilitate optic nerve regeneration. 67 Ultimately, optic nerve regeneration is going to

  • The progress in optic nerve regeneration, where are we?
  • Researchers discover a protein that stimulates optic nerve regeneration
  • Journal of Neuro-Ophthalmology

Our group is investigating the potential for exogenous electric field (EF) application as an approach to directing RGC axon regeneration. Electric fields naturally occur in the body

Stem cell-based treatment had become a promising frontier for treating neurodegenerative diseases, thus making it a potential therapeutic approach for optic

Recent studies indicate that certain growth factors can stimulate nerve regeneration. Evidence suggests that combining biological approaches with technological innovations can enhance recovery. Research into stem cell

Article. Optic nerve regeneration: Potential treatment approaches. Jessica Lee, Sherilyn Nguyen and Sanjoy Bhattacharya. Journal: Current Opinion in Pharmacology, 2024, Volume 74, Page

However, recent research advancements offer hope for clinically meaningful regeneration for those who suffer from optic nerve damage. In this review, we highlight the current treatment

Evolving therapeutic strategies long-distance regeneration, focusing proper axon guidance and of central targets to restore function. diseases nerve regeneration, offering a more prehensive

Restoration of vision in patients blinded by advanced optic neuropathies requires technologies that are neuroprotective approaches (prevent further degeneration of retinal ganglion cells [RGCs]), neuroregenerative approaches (salvage

Purpose of Review Traumatic optic neuropathy (TON) is a devasting disorder that can result in irreversible vision loss. Understanding the current research to promote

In this review, we highlight the current treatment approaches for optic nerve axon regeneration. Like other axons in the central nervous system (CNS), axons of the optic nerve

The optic nerve, comprising axons from retinal ganglion cells (RGCs), is a component of the central nervous system (CNS) that generally exhibits a limited regeneration capacity following

the optic nerve. Treatment involves high-dose intravenous corticosteroids in order to improve vision and reduce risk of developing multiple sclerosis. Nonarteritic AION presents as sudden

Researchers at The Ohio State University led by Dr. Benjamin Segal, professor and chair of the department of neurology at The Ohio State University Wexner Medical Center

To evaluate the potential clinical application of M1, the research team is now developing an animal model for treating glaucoma-related vision loss using M1. They may also

Further, growing evidence shows that adeno-associated virus gene transduction and stem cell-based RGC replacement therapy hold potential to treat optic nerve fiber

In this review, we summarize recent advances in therapeutic approaches targeting both intrinsic and extrinsic mechanisms of optic nerve regeneration and highlight emerging

Developing clinically effective treatments for optic nerve disease will require a collaborative approach that not only employs neurotrophic factors but also incorporates signals that promote

Here, we summarize recent advances in interventions targeting cell-intrinsic and cell-extrinsic mechanisms to enhance RGC axon regeneration. Additionally, we summarize strategies for

Developing clinically effective treatments for optic nerve disease will require a collaborative approach that not only employs neurotrophic factors but also incorporates signals that promote

Results: In this article, we discuss the different barriers to cell-replacement based strategies for optic nerve regeneration and provide an update regarding what progress that has

In this review article, we discuss the different barriers to strategies for optic nerve regeneration and provide an update regarding what progress that has been made to overcome them. We

Potential Optic Nerve Regeneration Approaches: Referenced from Optic Nerve Injury Models. Although many reports have found strategies to prevent RGC loss, few studies

Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention . Zhen-Gang Liu 1,2 † † Lai-Yang Zhou 2,3,4,5 † Yong-Quan Sun 2,3,4,5 Yi-Hang Ma 1 Chang-Mei Liu 2,3,4,5 * Bo

Several molecular neuro-protective and neuro-regenerative strategies have been proposed as potential treatments but do not provide the directional cues needed to direct target

Several steps are necessary for the successful treatment of optic nerve injuries. First, the death of RGCs that have been (or have the potential to be) damaged must be

Research over the past two decades has identified several strategies to enable RGCs to regenerate axons the entire length of the optic nerve, in some cases leading to

Although several approaches have been shown to promote substantial regeneration in vivo, the regrowth of sufficient numbers of axons through the entire optic

In the past two decades, tremendous progress has been achieved to enable RGC axon regeneration in animal models of optic nerve injury, which holds promise for neural repair