New Therapies For Advanced, Recurrent, And Metastatic Endometrial Cancers
Di: Everly
Whilst hormone therapy is recommended by ESMO-ESGO-ESTRO guidelines for the treatment of recurrent or advanced endometrial cancer [30,31], median PFS is low (3.0
Advanced and recurrent endometrial cancer: State of the art
This review provides a comprehensive overview of historical, current, and promising therapies in advanced and metastatic endometrial cancer. It particularly highlights
The FDA recently approved three new drugs for treating endometrial cancer. All three are a type of treatment known as immunotherapy.These work by increasing the immune
New targeted therapies are being identified for advanced and recurrent endometrial cancer. Within the last 5 years, pembrolizumab and lenvatinib have improved survival in
Robert L. Coleman, MD: Historically, the treatment options for patients with metastatic endometrial cancer were limited to chemotherapy and, for selected patients,
Endometrial cancer (EC) is the most common gynecologic malignancy, with worldwide increasing incidence and disease-associated mortality. Although most patients with
- New therapies for advanced, recurrent, and metastatic endometrial cancers
- First-line Treatment Options for Advanced Endometrial Cancer
- Management Strategies for Recurrent Endometrial Cancer
- Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer
In this review, we discuss current and emerging treatment options for endometrial cancer, including chemotherapy, targeted therapy, and immunotherapy.
Three drugs are newly approved for all advanced endometrial cancers
Heudel P, Frenel JS, Dalban C, Bazan F, Joly F, Arnaud A, et al. Safety and efficacy of the mTOR inhibitor, vistusertib, combined with anastrozole in patients with hormone receptor-positive
GSK. European Commission approves GSK’s Jemperli (dostarlimab), the first anti-PD-1 therapy approved for recurrent or advanced endometrial cancer.
Background: Patients with advanced or recurrent endometrial cancer (EC) typically have limited treatment options and poor long-term survival outcomes following first-line therapy. Real-world treatment patterns and
New therapies for advanced, recurrent, and metastatic endometrial cancers. Gynecol Oncol Res Pract. 2017;4(1):19. doi: 10.1186/s40661-017-0056-7 [PMC free article] [Google Scholar] 4.
This review provides a comprehensive overview of historical, current, and promising therapies in advanced and metastatic endometrial cancer. It particularly highlights clinical research on targeted and hormonal therapies,
Overview of recent trials evaluating role of targeted systemic therapies in the treatment of high-risk and metastatic endometrial cancer. Review of updates in molecular classification in endometrial cancer and impacts on
New therapies for advanced, recurrent, and metastatic endometrial cancers
Current Evidence-Based Systemic Therapy for Advanced and Recurrent Endometrial Cancer J Natl Compr Canc Memorial Sloan Kettering Cancer Center, New York, New York. 3
Expert Commentary: Endometrial cancer, though prevalent, remains underfunded and understudied. Recurrent and metastatic disease remains difficult to treat, and prospective
Immunotherapy has transformed the endometrial cancer treatment landscape, particularly for those exhibiting mismatch repair deficiency [MMRd/microsatellite instability-hypermutated (MSI-H)]. A growing body of
Anti programmed cell death protein-1 (PD-1) dostarlimab (TSR-042) was approved as monotherapy in patients with advanced, microsatellite instable (MSI) endometrial cancer
Endometrial Cancer “It’s been an exciting couple of years for endometrial cancer,” Friedman said. “We now have several new options for first-line treatment for patients with
Introduction. Endometrial cancer is the most common gynecologic malignancy in developed countries and the fifth leading cause of death among cancer patients worldwide. 1 It
New therapies for advanced, recurrent, and metastatic endometrial cancers. Review Overview abstract . Endometrial cancer is the most common gynecologic malignancy in the United
Treatment of Endometrial Cancer
417,000 new cases in 2020, mainly in Western countries. 1 In the last 20 years, its incidence has slowly increased by approximately 1% per year among postmenopausal women, accompanied
New targeted therapies are being identified for advanced and recurrent endometrial cancer. Within the last 5 years, pembrolizumab and lenvatinib have improved survival in
In this review, we discuss current and emerging treatment options for endometrial cancer, including chemotherapy, targeted therapy, and immunotherapy.
Endometrial cancer (EC) is the sixth most common cancer in women worldwide, with over 400,000 new cases per year; moreover, the incidence and mortality of this cancer are
Patients with metastatic disease face a significantly reduced 5-year survival rate of 16%, with a high likelihood of recurrence, particularly at sites outside the pelvic region. 3,4 For patients
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