Life, Death, And Autophagy In Cancer: Nf-Κb Turns Up Everywhere

Di: Everly

This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression. Escaping programmed cell

Roles of NF-κB in Cancer and Their Therapeutic Approaches | MDPI Books

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis

NF-κB is involved in the regulation of autophagy in mutant

Here, we review the role of NF-κB in apoptotic and necrotic PCD, the mechanisms involved, and how its activity in the cell death response impacts cancer development, progression, and therapy.

The cellular response to survive or to undergo death is fundamental to the benefit of the organism, and errors in this process can lead to autoimmunity and cancer. The transcription factor

Here, we summarize and discuss the most recent discoveries that shed new light on the complex interplay between autophagy and NF-κB signaling pathways; this certainly has functional relevance in tumorigenesis and tumor responses to

Life, death, and autophagy in cancer: NF-κB turns up everywhere
Autophagy and NF-κB: Fight for fate
Life, death and autophagy

Chemotherapy and ionizing radiation (IR) can induce autophagy in tumor cells. Here, we report that the level of autophagy in tumor cells was related to the background of p53

This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.

Tight regulation of both the NF-κB pathway and the autophagy process is necessary for maintenance of cellular homeostasis. Deregulation of both pathways is frequently observed in

生物提取物小白菊内酯抗肿瘤作用及机制的研究进展

Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review

Verzella, D., Pescatore, A., Capece, D., Vecchiotti, D., Ursini, M. V., Franzoso, G., Zazzeroni, F. (2020). Life, death, and autophagy in cancer: NF-κB turns up

Activation of NF-κB has been linked to various cellular processes in cancer, including inflammation, transformation, proliferation, angiogenesis, invasion, metastasis, chemoresistance, and radioresistance. Although acute

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis

While the roles of NF-κB in promoting cell survival in lymphocytes and in cancers is relatively clear, evidence has been presented that NF-κB can promote cell death in particular contexts.

Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review

Life, death, and autophagy in cancer: NF-κB turns up everywhere. 2020, Cell Death and Disease . Show abstract. Escaping programmed cell death is a hallmark of cancer. NF-κB

Abstract. Activation of NF-κB has been linked to various cellular processes in cancer, including inflammation, transformation, proliferation, angiogenesis, invasion,

Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This

Current understanding of autophagy is reviewed, with a focus on its role in tumor suppression, NF-kappaB inactivation and selective protein degradation in mammals, and some most

NF-κB transcription factors are central regulators of TAMs in cancers, where they often drive macrophage polarization toward an M2-like phenotype. Therefore, the NF-κB

The most extensively studied function of NF-κB is its ability to promote cell survival through induction of target genes, whose products inhibit various aspects of the apoptotic machinery in

NF-κB signaling pathway in cancer stem cells. The top of the diagram ...

This review discusses how the reciprocal regulation of NF-?B, autophagy and programmed cell death affect cancer development and progression. Department of Biotechnological and Applied

Semantic Scholar extracted view of „Autophagy and NF-κB: Fight for fate“ by G. Xiao. Semantic Scholar extracted view of „Autophagy and NF-κB: Fight for fate“ by G. Xiao. Skip to search

Here, we report that the level of autophagy in tumor cells was related to the background of p53 gene that NF-κB acts as a negative regulator of autophagy in mutant p53

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the

TLR4 stimulation activates autophagy by inducing the ubiquitination (Ub represents ubiquitin) of Beclin 1 by TRAF6, an upstream activator of NF-κB. In turn, NF-κB activation upregulates the

批注本地保存成功，开通会员云端永久保存去开通

Tight regulation of both the NF-κB pathway and the autophagy process is necessary for maintenance of cellular homeostasis. Deregulation of both pathways is frequently observed in

Semantic Scholar profile for Daniela Verzella, with 43 highly influential citations and 39 scientific research papers.

GORT

Reviews