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Inhibition Of Rev-Erbα Ameliorates Muscular Dystrophy

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Rev-Erbα and ROR antagonists inhibited the activation of the ...

Inhibition of Rev-erbα Ameliorates Muscular Dystrophy

Here we show that Rev-erbα deficiency in the dystrophin-deficient mdx mice promotes regenerative myogenic response to ameliorate muscle damage. Loss of Rev-erbα in

加えて、rev-erbαは、脂質およびグルコース代謝などの代謝過程を調節することも示されています。sr8278は、合成アゴニストgsk4112がrev-erbαに依存して抑制を促進する能力を阻害し

Highlights: • Rev-erbα ablation in mdx mice protects against muscle damage and wasting. • Loss of Rev-erbα promoted regenerative myogenesis in mdx mice. • Rev-erbα

Inhibition of Rev-erbα ameliorates muscular dystrophy. Experimental Cell Research, 406(2), 112766. doi:10.1016/j.yexcr.2021.112766

  • REV‐ERBα activates the mTOR signaling pathway and
  • Inhibition of Rev-erb alpha ameliorates muscular dystrophy
  • REV-ERBs: More than the sum of the individual parts
  • Inhibition of Rev-erbα Ameliorates Muscular Dystrophy.

Here we show that Rev-erbα deficiency in the dystrophin-deficient mdx mice promotes regenerative myogenic response to ameliorate muscle damage. Loss of Rev-erbα in

Inhibition of Rev-erbα Ameliorates Muscular Dystrophy.

Inhibition of Rev-erbα Ameliorates Muscular Dystrophy. Article. Aug 2021 ; Xuekai Xiong; Hongbo Gao; Yayu Lin [] Ke Ma; Duchene muscular dystrophy leads to progressive muscle structural and

Results We studied the effect of REV‐ERBα overexpression and silencing as well as mTORC1 activation and inhibition on the differentiation of C2C12 myoblasts to myotubes.

Collectively, our findings revealed that the loss of Rev-erbα function protects dystrophic muscle from injury by promoting myogenic repair, and inhibition of its activity may have therapeutic

We therefore explored whether disrupting REV-ERB activity using the REV-ERB antagonist SR8278 could slow the progression of muscular dystrophy in a model of DMD, the mdx mouse.

Inhibition of Rev-erbα ameliorates muscular dystrophy. Myonuclear transcriptional dynamics in response to exercise following satellite cell depletion. Skeletal muscle atrophy:

Moreover, pharmacological inhibition of Rev-erbα by an antagonist, SR8278, attenuated myogenic progenitor properties in regenerative myogenesis that ameliorates muscular dystrophy. Here we

Download scientific diagram | Rev-erbα inhibits myoblast proliferation. (A) RT-qPCR analysis of Rev-erbα and Bmal1 mRNA in quadriceps of WT and Rev−/− mice (n = 6/group). (B–G)

Here we show that Rev-erbα deficiency in the dystrophin-deficient mdx mice promotes regenerative myogenic response to ameliorate muscle damage. Loss of Rev-erbα in

Mps1 Is Required for Normal Muscle Regeneration and

Download scientific diagram | Rev-erbα expression and dynamic regulation in skeletal muscle and myoblasts. (A) Immunoblot analysis of time-dependent expression profile of Rev-erbα protein

Download scientific diagram | Rev-erbα regulation of Wnt pathway gene expression and signaling activity. (A) RT-qPCR analysis of Wnt pathway gene expression in WT and Rev−/− primary

The nuclear receptor REV-ERB suppresses myoblast differentiation and recently we have demonstrated that the REV-ERB antagonist, SR8278, stimulates muscle regeneration

Here we show that Rev-erbα deficiency in the dystrophin-deficient mdx mice promotes regenerative myogenic response to ameliorate muscle damage. Loss of Rev-erbα in

REV-ERB is an inhibitor of myogenesis in myoblasts and pharmacological antagonism of REV-ERB stimulates muscle regeneration during acute injury 27,28,29.

Semantic Scholar extracted view of „Inhibition of Rev-erbα Ameliorates Muscular Dystrophy.“ by Xuekai Xiong et al.

Duchene muscular dystrophy leads to progressive muscle structural and functional decline due to chronic degenerative-regenerative cycles. Enhancing th..

We previously demonstrated that the circadian clock repressor Rev-erbα inhibited myogenesis and Rev-erbα ablation enhanced muscle regeneration. Here we show that Rev

Moreover, pharmacological inhibition of Rev-erbα by an antagonist, SR8278, attenuated myogenic progenitor properties in regenerative myogenesis that ameliorates muscular

Here we show that Rev-erbα deficiency in the dystrophin-deficient mdx mice promotes regenerative myogenic response to ameliorate muscle damage. Loss of Rev-erbα in mdx mice

Download scientific diagram | Rev-Erb regulates Wnt signaling downstream of Wnt receptor activation in muscle cells. (A) Expression of the Wnt target genes Axin2, Ctnnb1 and Tcf3 in response to

In mdx myoblasts devoid of Rev-erbα, myogenic differentiation was augmented together with up-regulation of Wnt signaling and proliferative pathways, suggesting that loss of

Inhibition of Rev-erbα ameliorates muscular dystrophy. Xiong X, Gao H, Lin Y, Yechoor V Circadian Clock in Muscle Disease Etiology and Therapeutic Potential for

Moreover, pharmacological inhibition of Rev-erbα by an antagonist, SR8278, attenuated pathophysiological changes in the mdx model (65), providing the proof-of-principle validation

REV-ERB is an inhibitor of myogenesis in myoblasts and pharmacological antagonism of REV-ERB stimulates muscle regeneration during acute injury 27 – 29.

REV-ERB is an inhibitor of myogenesis in myoblasts and pharmacological antagonism of REV-ERB stimulates muscle regeneration during acute injury 27–29. Therefore, we postulated that