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Age-Associated B Cells In Autoimmune Diseases

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A unique B cell population, termed age-associated B cells (ABCs), was identified in 2011 in the contexts of aging and autoimmunity [1,2]. The frequency of ABCs increases with age, particu

Age-associated B cells (ABCs) are a distinct subset of B cells. This B-cell population expands in the elderly but is also abnormally expanded in patients with autoimmune diseases like

Cells | Free Full-Text | Aberrant B Cell Signaling in Autoimmune Diseases

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Keywords: age-associated B cells, inflammatory arthritis, autoimmune diseases, immunopathogenesis, therapeutic target. Citation: Li Z-y, Cai M-L, Qin Y and Chen Z (2023)

Age-associated B cells (ABCs) have emerged as critical components of immune responses. Their inappropriate expansion and differentiation have increasingly been linked to the pathogenesis of autoimmune disorders, aging-associated

AGE-ASSOCIATED B CELLS The importance of B cells expressing T-bet in autoimmune disease was first demonstrated in 2002, using a murine lupus model with B

Fig. 1 Age-associated B cells in health versus autoimmune disease Age-associated B cells (ABCs) dierentiate from a combina-tion of signals that include BCR stimulation and TLR7/9

  • Age associated B cells and their relatives
  • Age-associated B cells in autoimmune diseases.
  • The role of age-associated B cells in systemic lupus erythematosus
  • Age-associated B cells in autoimmune diseases

As a heterogeneous B cell subset, age-associated B cells (ABCs) exhibit distinct transcription profiles, extrafollicular diferen-tiation processes, and multiple functions in autoimmunity.

Age-associated B cells (ABCs) have emerged as critical components of immune responses. Their inappropriate expansion and differentiation have increasingly been linked to the pathogenesis

Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell population. In addition to arising with age and following infection, ABCs are expanded during

Age-associated B cells in autoimmune diseases

In addition, they are elevated in autoimmune and autoinflammatory diseases, and in these settings they are enriched for characteristic autoantibody specificities. Together, these features

Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems and complex pathogenesis. It results in the activation of innate and adaptive immunity, in which the

Age-associated B cells (ABCs) accumulate during infection, aging, and autoimmunity, contributing to lupus pathogenesis. In this study, we screened for transcription

Download scientific diagram | Age-associated B cells in health versus autoimmune disease Age-associated B cells (ABCs) differentiate from a combination of signals that include BCR

DN2 B cells overlap with “age-associated B cells” that increase with age , perhaps contributing to the age-related risk for autoimmune diseases. However, the relationship

The term „age-associated B cells“ (ABCs) refers to a heterogeneous B cell subset (CD19 +,CD21-, CD11c +,T-bet +) which is expanded in the elderly, but also

The term “age-associated B cells” (ABCs) refers to a heterogeneous B cell subset (CD19 + ,CD21 – ,CD11c + ,T-bet + ) which is expanded in the elderly, but also accumulates prematurely in

Function and Regulation of Age-Associated B Cells in Diseases

Age-associated B cells (ABCs) accumulate during infection, aging, and autoimmunity, contributing to lupus pathogenesis. In this study, we screened for transcription factors driving ABC formation and found that zinc finger E-box

In autoimmune disease, B cells orchestrate antigen presentation, cytokine production and autoantibody production, the latter via their differentiation into antibody

ZEB2 Acts as a Crucial Transcriptional Regulator Governing Age ...

Increased markers of immune deregulation at the second point measurement are associated with increased age. We then analyzed the measured parameters at the second

It has become clear that epigenetic regulation of functional B-cell subsets is involved in the development of various autoimmune diseases murine CD11c+ age

Age-associated B cells (ABCs) are characterized by CD11c and T-bet expression. ABCs are elevated in several autoimmune diseases and may be associated with RA. This

For example, basic research and clinical results have revealed that B cells play important roles in autoimmune diseases, roles that are independent of the ability of their

Summary of the development and pathogenic role of age-associated B cells (ABCs) in autoimmunity. ABCs develop in the setting of polarizing cytokines, B cell receptor

Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell population. In addition to arising with age and following infection, ABCs are expanded during

Thus, this subset was termed age-associated B cells, or ABCs, and this abbreviation is often still used. 17 A companion article from Michael Cancro’s lab identified a

The term “age-associated B cells” (ABCs) refers to a heterogeneous B cell subset (CD19+,CD21−, CD11c+,T-bet+) which is expanded in the elderly, but also accumulates prematurely in patients

We conducted an extensive analysis of CD4 + T cell subsets from 354 patients with autoimmune disease and healthy controls via flow cytometry and bulk RNA sequencing.

This age-associated epigenetic reprogramming disrupts the delicate Th1/Th2 balance, amplifying Th1-driven inflammation and contributing to the onset of autoimmune

Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell population. In addition to arising with age and following infection, ABCs are expanded during autoimmune

ZEB2 drives the differentiation of age-associated B cell in autoimmune diseases Sci Bull (Beijing) . 2024 May 30;69(10):1362-1364. doi: 10.1016/j.scib.2024.03.041.