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Adult Stem Cells For Tissue Repair — A New Therapeutic Concept?

Di: Everly

In the adult organism, some tissues and organs are endowed with adult stem cells, which ensure the natural cycles of tissue turnover and homeostasis seen, e.g., in the skin,

Adult stem cells for tissue repair-a new

Adult Stem Cells for Tissue Repair — A New Therapeutic Concept? | NEJM

Using adult stem cells to generate or repair solid organ tissue obviates the immunologic, ethical, and teratogenic issues that accompany embryonic stem cells.

The identification of reservoirs of multipotential stem cells within adult tissue provides exciting prospects for novel therapeutic approaches, such as cell-based tissue

This review focuses on in vivo models of adult stem cells derived from bone marrow and peripheral blood and their potentially novel therapeutic applications. Adult human stem cells

  • Stem Cell Therapy in Perspective
  • Enabling stem cell therapies for tissue repair: current and future
  • Therapeutic pathways of adult stem cell repair

Embryonic stem cells have the advantage of an unequaled pluripotent differentiation plasticity associated with a robust repair capacity, yet access for clinical applications remains a

Among these new therapeutic options, because of their strong cytokine profile, their immunomodulating properties, and their potential for multilineage differentiation, stem-cell

Stem cell therapy is a novel therapeutic approach that utilizes the unique properties of stem cells, including self-renewal and differentiation, to regenerate damaged cells

Recent data suggest that adult stem cells generate differentiated cells beyond their own tissue boundaries, a process termed “developmental plasticity.” In this review we focus on in vivo

The general principle for stem cell therapies is to exploit the natural ability of the human body to heal tissues in part through regeneration. One simple example of this process

Stem cells hold the key to replacing cells lost in many diseases that are caused by loss of functioning cells. The unique capability of this cell to form various tissues under definite

The recruitment of endogenous repair mechanisms to promote tissue regeneration in situations in which it does not normally occur has long been a goal in biomedical science.

The concept of using embryonic stem (ES) cells as a source of multiple cell types for use in tissue repair has existed for approximately 20 years. Recent breakthroughs in somatic

In this review, the possible role of stem/progenitor cells in the physiological cell turnover, liver, and biliary disease progression and regenerative activity and the potential

Emerging evidence in regenerative medicine and stem cell research suggests the treatments are safe, whereas their therapeutic potential, effectiveness, and mode of action

The concept of using embryonic stem (ES) cells as a source of multiple cell types for use in tissue repair has existed for approximately 20 years. Recent breakthroughs in somatic

Whereas embryonic stem cells are derived from mammalian embryos in the blastocyst stage and have the ability to generate any terminally differentiated cell in the body, adult stem cells are

Adult stem cells - imagingnipod

Here we provide a summary of the requirements for stem cell repair including, cell recruitment, immunomodulation and neo-angiogenesis. Table 1. Adult stem cell therapies. List

Analysis of recent data suggests that adult stem cells can generate differentiated cells beyond their own tissue boundaries, a process termed “developmental stem-cell

One potential reason why stem cell therapies have failed to impact human disease is that our concept of stem cells is loosely defined and highly imprecise (Tajbakhsh,

Some of these issues will be reviewed in this study with special emphasis on how they can be applied to the adult stem/progenitor cells from bone marrow, referred to as MSCs.

Spinal cord injury (SCI) is a debilitating neurological condition that leads to severe disabilities, significantly reducing patients’ quality of life and imposing substantial societal and

Here, we present an update on stem cell applications for tissue regeneration, their limitations, specifically in the context of disease states such as aging and diabetes, and novel

Tissue stem cells (SCs) design their niches and communicate with a plethora of cell types to orchestrate homeostasis and injury-induced repair. Here, Elaine Fuchs and Helen

Recently, adult stem cells originating from bone marrow or peripheral blood have been suggested to contribute to repair and genesis of cells specific for liver, cardiac and skeletal muscle, gut,

Adult stem cells for tissue repair – A new therapeutic concept? / Körbling, Martin; Estrov, Zeev. In: New England Journal of Medicine, Vol. 349, No. 6, 07.08.2003, p. 570-582. Research output:

Adult human stem cells that are intrinsic to various tissues have been described and characterized, some only recently.